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Information Journal Paper

Title

PREDICTION OF SILVER NANOPARTICLES INTERACTION WITH L- LACTATE DEHYDROGENASE (LDH1) INTOXOPLASMA GONDII

Pages

  304-304

Keywords

SILVER NANOPARTICLES (AG NPS) 

Abstract

 The aim of present study was to study bioinformatic interaction of silver nanoparticles (Ag NPs) and L- LACTATE DEHYDROGENASE enzymein TOXOPLASMA GONDII to determine harmful effect of silver nanoparticle on the enzyme. In this study we used Metal Detector Predicts v2.0 software, DiANNA 1.1 web server, Molecular docking web server and 3D Ligand Site server, to analyze enzyme structure and Ag NPs inhibitory effect on its function. The results obtained from docking showed that free energy of binding from docking score for L- LACTATE DEHYDROGENASE was -3.83 kcal/mol and inhibition constant (Ki) equal to 1.56 mM. Ag NPs may facilitate the interaction with Cysteine in 10 positions of enzyme. Ag NPs naturally interact with the membrane of pathogens and disrupt the membrane integrity, and silver ions bind to sulfur, oxygen, and nitrogen of essential biological molecules and inhibit pathogens growth.

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    APA: Copy

    TAKTAZ, FATEMEH, & TAKTAZ, MOHAMMAD. (2014). PREDICTION OF SILVER NANOPARTICLES INTERACTION WITH L- LACTATE DEHYDROGENASE (LDH1) INTOXOPLASMA GONDII. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 304-304. SID. https://sid.ir/paper/335954/en

    Vancouver: Copy

    TAKTAZ FATEMEH, TAKTAZ MOHAMMAD. PREDICTION OF SILVER NANOPARTICLES INTERACTION WITH L- LACTATE DEHYDROGENASE (LDH1) INTOXOPLASMA GONDII. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):304-304. Available from: https://sid.ir/paper/335954/en

    IEEE: Copy

    FATEMEH TAKTAZ, and MOHAMMAD TAKTAZ, “PREDICTION OF SILVER NANOPARTICLES INTERACTION WITH L- LACTATE DEHYDROGENASE (LDH1) INTOXOPLASMA GONDII,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 304–304, 2014, [Online]. Available: https://sid.ir/paper/335954/en

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