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Title

EARLY ENDOCRINE DISRUPTORS EXPOSURE ACTS ON 3T3-L1 DIFFERENTIATION AND ENDOCRINE ACTIVITY

Pages

  83-89

Abstract

 Introduction: Data from last years suggested that early exposure to ENDOCRINE DISRUPTORS (EDs) can predispose newborns to endocrine dysfunction of adipocytes, obesity, and associated disorders. The implication of EDs at low doses on adipocyte development has been poorly investigated. For instance, VINCLOZOLIN (V) is a dicarboximide fungicide widely used in agriculture since the 90’ s, alone or in mixture with GENISTEIN (G), an isoflavonoid from Leguminosae. This study aims to identify the effect of VINCLOZOLIN alone or with GENISTEIN, on ADIPOSE TISSUE properties using cell culture.Methods: In steroid-free conditions, 3T3-L1 pre-adipocytes were induced to differentiate in the presence of EDs, singularly or in mixtures, for 2 days. DNA and TRIGLYCERIDE (TG) levels were measured on days 0, 2 and 8 of differentiation. LEPTIN secretion was measured only on the eighth day.Results: We show that low doses of G (25 mM) and V (0.1 mM) inhibit pre-adipocytes differentiation. This inhibition has been represented by a decreasing in DNA content (mg/well) and decreasing in TG accumulation (mg/mL) in 3T3-L1 cells. Nevertheless, V increased the anti-adipogenic properties of G.Conclusion: This study confirms that EDs singularly or in mixtures, introduced during early stages of life, could affect the differentiation and the endocrine activity of adipocytes, and can act as potential factors for obesity.

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    APA: Copy

    BOUDALIA, SOFIANE, BELLOIR, CHRISTINE, MILLER, MARIE LOUISE, & CANIVENC LAVIER, MARIE CHANTAL. (2017). EARLY ENDOCRINE DISRUPTORS EXPOSURE ACTS ON 3T3-L1 DIFFERENTIATION AND ENDOCRINE ACTIVITY. BIOIMPACTS, 7(2), 83-89. SID. https://sid.ir/paper/334078/en

    Vancouver: Copy

    BOUDALIA SOFIANE, BELLOIR CHRISTINE, MILLER MARIE LOUISE, CANIVENC LAVIER MARIE CHANTAL. EARLY ENDOCRINE DISRUPTORS EXPOSURE ACTS ON 3T3-L1 DIFFERENTIATION AND ENDOCRINE ACTIVITY. BIOIMPACTS[Internet]. 2017;7(2):83-89. Available from: https://sid.ir/paper/334078/en

    IEEE: Copy

    SOFIANE BOUDALIA, CHRISTINE BELLOIR, MARIE LOUISE MILLER, and MARIE CHANTAL CANIVENC LAVIER, “EARLY ENDOCRINE DISRUPTORS EXPOSURE ACTS ON 3T3-L1 DIFFERENTIATION AND ENDOCRINE ACTIVITY,” BIOIMPACTS, vol. 7, no. 2, pp. 83–89, 2017, [Online]. Available: https://sid.ir/paper/334078/en

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