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Title

Neoangiogenesis in Benign and MalignantSalivary Gland Tumors

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 Start Page 37 | End Page 42

Abstract

 Introduction: There are few studies investigating the role of neoangiogenesis in biologicalbehavior of salivary gland tumors. CD105 expression has demonstrated greater accuracy fordetecting new vessel formation compared with other pan-endothelial molecules. This studyaimed to assess and compare intratumoral Micro-Vessel Density (MVD) through usingimmunohistochemichal expression of CD105 biomarker in Mucoepidermoid Carcinoma(MEC), Adenoid Cystic Carcinoma (AdCC) and Pleomorphic Adenoma (PA). Materials and Methods: CD105 expression using Immunohistochemistry (IHC) wasassessed in 20 cases of PA, 20 cases of AdCC, 20 cases of MEC, and 10 cases of normalsalivary gland tissues. Positive intratumoral micro-vessels for CD105 expression weremeasured quantitatively for the assessment of Micro-Vessel Density (MVD) in each group. Groups differences in MVD was analyzed statistically using the Mann-Whitney U test andKruskal-Wallis test. One-way ANOVA and post hoc Tukey test were also carried out. P valuesless than 0. 05 were considered statistically significant. Results: CD105 positive vessels were rarely seen in normal salivary gland tissue. Statisticallysignificant differences in MVD were observed between the normal salivary gland tissue andAdCC and also MEC (P<0. 017 and P<0. 001, respectively). There was a statistically significantdifference in MVD between PA and AdCC and also MEC (P<0. 018 and P<0. 001, respectively). MVD was higher in MEC in comparison with AdCC (P<0. 002). Conclusion: The results of the current study demonstrated higher neoangiogenesis in AdCCand MEC by measuring CD105 expression, which suggests a possible role for this phenomenonin aggressive behavior of these malignant salivary gland tumors.

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