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Information Journal Paper

Title

PRELIMINARY DATA SUGGEST POSSIBLE ASSOCIATION BETWEEN IL-32 EXPRESSION LEVEL AND TIME OF MS ATTACK

Pages

  44-49

Keywords

Not Registered.

Abstract

 IL-32 and TNFaare important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNFa transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference inIL-32 and TNFa mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels ofIL-32mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features.

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