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Title

THE EFFECT OF ENOXAPARIN AND CLOPIDOGREL ON SURVIVAL OF RANDOM SKIN FLAP IN RAT ANIMAL MODEL

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 Start Page 64 | End Page 70

Abstract

 BACKGROUND: Necrosis of SKIN FLAPs is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, CLOPIDOGREL and their combination to improve the flap SURVIVAL.METHODS: Forty male, adult Sprague-Dawlay RATs were divided randomly into 4 groups. Standard rectangular, distally based dorsal random pattern SKIN FLAP was elevated. To prevent the graft effect, a sterile sheet was put under the flap. No pharmacological agent was administered for the control group. In group 2, single subcutaneous dose of ENOXAPARIN (3.2 mg/kg) was immediately administrated after surgery. In group 3, CLOPIDOGREL (25 mg/kg) was given orally for 7 days. In group 4, both ENOXAPARIN and CLOPIDOGREL were administrated. The RATs were evaluated on post-operative day 7 for viable and necrotic portions of flaps.RESULTS: The mean and SD of necrosis was 17.79 ±2.5 cm in the control group, 16.20±3.1 cm in low-molecular weight heparin, 15.25±3.8 cm in combined therapy group and 13.69±2.7 cm in CLOPIDOGREL group. CLOPIDOGREL was the only pharmaceutical agent that produced a significant increase in the flap SURVIVAL area.CONCLUSION: CLOPIDOGREL may be an effective pharmaceutical agent that significantly increases viability of random SKIN FLAPs in RATs, but low-molecular weight heparin and their combination did not have any significant beneficial effects.

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