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Title

DETERMINATION OF ANTIBIOTIC SUSCEPTIBILITY AND MINIMUM INHIBITORY CONCENTRATION (MIC) OF THE PROPIONIBACTERIUM ACNES TO THE PREVALENT ANTIBIOTICS IN THE TREATMENT OF ACNE VULGARIS

Writers

NAGHDI NEGIN | GHANE MASOOD

Pages

 Start Page 543 | End Page 548

Abstract

 Propionibacterium acnesis propounded as one of the significant agent in the occurrence of acne. Due to development of the ANTIBIOTIC RESISTANCE, most of the ACNE VULGARIS treatments are faced with failure. In order to determine the ANTIBIOTIC RESISTANCE of the P. acnes strains isolated from the patients with ACNE VULGARIS, this research has been carried out.70 samples collected using microbial culture technique were studied to identify P. acnes. Antibiotic susceptibility of the strains isolated by antibiogram method and serial dilution to suitable antibiotics including Erythromycin, Clindamycin and Tetracycline was shown to be the preferred antibiotics in the acne treatment. Of total 70 studied samples, 14 positive samples (20%) were identified for the presence of P. acnes. The frequency of antibiotic susceptibility to Erythromycin, Clindamycin and Tetracycline was determined to be 50%, 64.28% and 85.71%, respectively. Range of MIC for Erythromycin, Clindamycin and Tetracycline were 0.125-64mg/ml, 0.25-16 mg/ml and 0.063-16 mg/ml, respectively The frequency of ANTIBIOTIC RESISTANCE of the P. acnes to Erythromycin and Clindamycin was high. Since P. acnes is significantly sensitive to Tetracycline, it is recommended that this antibiotic to be used for the treatment of acne.

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