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Title

POLYMORPHISM OF THE IL-18 AND CD40 GENES AND LIVER TRANSPLANT OUTCOME IN IRANIAN PATIENTS

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 Start Page 146 | End Page 154

Abstract

 Background: Cytokines and co-stimulatory molecules are important factors determining the outcome of transplantation.Objective: To investigate the effect of IL-18 and CD40 gene POLYMORPHISMs on the outcome of LIVER TRANSPLANTATION.Methods: 150 liver transplant recipients were included in this study. Alleles and genotypes frequencies for IL-18 (rs1946519) and CD40 (rs1883832) were determined in 28 acutely rejected (AR group) and 122 non-acutely rejected (non-AR group) liver transplant recipients. IL-18 and CD40 gene POLYMORPHISMs were evaluated by PCR-RFLP methods.Results: There were no significant associations between IL-18 and CD40 POLYMORPHISM with acute rejection in liver transplant patients. IL-18TT and TG genotypes had a significant association with rejection in women compared to men. After grouping the liver recipients according to living vs cadaver donors, a significant association was found between CC genotype of CD40 and rejection in male living donor recipients. IL-18 TG genotype had a significant association with rejection in female cadaver donor recipients.Conclusion: There is no correlation between all genotype and alleles of IL-80 and CD40 POLYMORPHISM and the outcome of LIVER TRANSPLANTATION. However, gender and type of donor affect the correlation between all genotype and alleles of IL-18 and CD40, and the outcome of LIVER TRANSPLANTATION.

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