Journal Paper

Paper Information

Journal:
Year:0 | Volume: | Issue:
Start Page: | End Page:

video

sound

Persian Version

View:

21,264

Download:

0

Cites:

Information Journal Paper

Title

PHOTOBIOMODULATION AND PHOTOBIOINHIBITION OF CANCER STEM CELLS

Writers

ABRAHAMSE HEIDI

Pages

 Start Page 1 | End Page 1

Keywords

Not Registered.

Abstract

 Background: Cancer stem cells (CSCs) have been implicated as an important contributory factor in the development of metastasis. CSCs have the same characteristics as normal stem cells; they can proliferate indefinitely and are capable of both self-renewal and differentiating into specialized cells. The molecular and cellular characteristics of stem cells and CSCs are coded for by cell-specific genes, which can be analysed using molecular assays. Low-intensity laser irradiation (LILI) has been applied in the treatment of numerous diseases and pathological conditions. Photobiomodulation has been shown to stimulate proliferation of cells, capillary growth, and cellular metabolism as observed by ATP activation. It has been shown, by using different fluences and wavelengths, LILI, can either stimulate or inhibit cellular functions. Cancer research is highly focused on improving current cancer treatments. One of the methods of targeted cancer therapy is photodynamic therapy (PDT), where LILI, along with a photochemical compound, is used. When implementing a mechanism by which CSCs are targeted, LILI might be a viable treatment option. Studies have shown that using high fluences of LILI (HF-LILI) cell death may be induced in normal and neoplastic cells.Methods: In our work, lung and breast CSCs were isolated using stem cell markers and irradiated at wavelengths of 636, 825 and 1060 nm, with fluences ranging from 5 J/cm2 to 40 J/cm2. Post-irradiation biochemical assays were conducted after 24 hours to monitor cellular responses including proliferation and cytotoxicity3.Results: Lung, cervical and breast CSCs were successfully isolated from cancer cells using stem cell markers and fluorescent imaging to confirm characteristics.Conclusion: Results indicate that LILI, when treating CSCs, can induce either a bio-stimulatory or bioinhibitory effect depending on the wavelength and fluence used. This study indicated successful cell damage in CSCs when using HF-LILI, as well as, stimulation of ATP production when using lower fluences of LILI.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    File Not Exists.