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Information Journal Paper

Title

DEVELOPMENT OF SYSTEMIC SCLEROSIS IN PATIENTS WITH AUTOIMMUNE HEPATITIS: AN EMERGING OVERLAP SYNDROME (CASE SERIES)

Pages

  211-219

Abstract

 Aim: We described two case reports of AIH/SSc overlap syndrome and reviewed literatures regarding this issue.Background: AIH is a chronic hepatitis of unknown aetiology characterized by continuing hepatocellular necrosis and inflammation. AIH overlap syndromes have been reported with other autoimmune diseases.Patients and methods: According to the classification criteria for SSc, we conducted a retrospective chart review of 35 cases with biopsy-proven AIH over the past 5 years at our institution. We reviewed the MEDLINE database using the appropriate key-words.Results: A chart review of 35 cases (M/F ratio 1:2, mean age 47.6±10.3 years) revealed nine patients (9.35, 25.7%) with CTD (four males and three females with a mean age of 45.1±8.4 years). All patients had ANA. Four patients were SSA/Ro positive UCTD (1.35, 2.85%), and six patients developed SLE (6.35, 17.1%). Only two female patients (2.35, 5.7%) with specific SSc AAb developed a SYSTEMIC SCLEROSIS. We described a patient with AIH who was diagnosed with diffuse SYSTEMIC SCLEROSIS-sine scleroderma with positive anti-centromere B and SSA/Ro52 KDa antibodies. We also reported a patient with AIH who was diagnosed limited SSc with contemporary presence of anti-centromere A and anti-RNA polymerase III antibody.Conclusion: We suggest that SSc may be considered to be one of the manifestations associated with AIH. Patients with AIH may have an increased risk to develop SSc and should be followed, especially when Raynaud phenomenon was found.

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    Cite

    APA: Copy

    ASSANDRI, R., & MONARI, M., & MONTANELLI, A. (2016). DEVELOPMENT OF SYSTEMIC SCLEROSIS IN PATIENTS WITH AUTOIMMUNE HEPATITIS: AN EMERGING OVERLAP SYNDROME (CASE SERIES). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 9(3), 211-219. https://sid.ir/paper/324662/en

    Vancouver: Copy

    ASSANDRI ROBERTO, MONARI MARTA, MONTANELLI ALESSANDRO. DEVELOPMENT OF SYSTEMIC SCLEROSIS IN PATIENTS WITH AUTOIMMUNE HEPATITIS: AN EMERGING OVERLAP SYNDROME (CASE SERIES). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH. 2016 [cited 2023January29];9(3):211-219. Available from: https://sid.ir/paper/324662/en

    IEEE: Copy

    ASSANDRI, R., MONARI, M., MONTANELLI, A., 2016. DEVELOPMENT OF SYSTEMIC SCLEROSIS IN PATIENTS WITH AUTOIMMUNE HEPATITIS: AN EMERGING OVERLAP SYNDROME (CASE SERIES). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, [online] 9(3), pp.211-219. Available: https://sid.ir/paper/324662/en.