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Title

The Age-standardized Incidence Rate ofOvarian Cancer in Iranian Women: A Systematic Review and Meta-analysis

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 Start Page 171 | End Page 178

Abstract

 Background: Cancer is the leading cause of morbidity and mortality worldwide. Among gynecological cancers, ovarian cancer is the first cause of cancer-relateddeaths. However, only a few studies have evaluated the age-standardized Incidence rateof ovarian cancer in Iranian women. Therefore, the present study aims to systematicallyreview the age-standardized Incidence rate of ovarian cancer in Iran. Methods: We systematically reviewed the literature that pertained to the Incidencerate of ovarian cancer among Iranian women. In May 2016, we performed searchesof national scientific databases that included SID, Magiran, IranMedex, and IranDoc. Searches of international databases included PubMed, Scopus, and ScienceDirect. Theretrieved studies were then assessed according to the study’ s inclusion criteria. Results: In this review, we included 14 from 115 articles obtained through searchingnational and international databases, grey literature, and hand searching. Based on therandom effects model, the age-standardized Incidence rate of ovarian cancer was 3. 19(95% CI: 2. 78-3. 59). Conclusion: The study results indicated that the age-standardized Incidence rateof ovarian cancer was considerably low in Iran. The registration methodology normallyused by cancer registries has probably led to an underestimation of the Incidence rateof ovarian cancer among Iranian women. Thus, we recommend the establishment ofcancer registries that cover a broader population.

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