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Title

THE EFFECT OF POLYMORPHISM IN NAD (P) H: QUININE OXIDOREDUCTASE ON LIVER FUNCTION TESTS AND HEMATOLOGIC PARAMETERS IN WORKERS EXPOSED TO SOUR GAS

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SAEEDI A. | MANDEGARI A.

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 Start Page 46 | End Page 46

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Abstract

 Background: Many pollutants in the environment increase the blood level of free radicals. This problem is more pronounced in environments with high levels of potentially toxic and carcinogenic chemicals. The enzyme NAD (P) H: quinine oxidoreductase (NQO1) has an important role in detoxifying environmental toxic agents. "Sour gas" is a natural gas containing significant amounts of hydrogen sulfide (H2S); Natural gas that does not contain high amounts of H2S is termed "sweet gas."Objective: To determine the effect of NQO1 polymorphism on liver function tests and hematologic parameters in workers exposed to sour gas.Methods: In a cohort study, 120 workers exposed to sour and sweet gases and 93 office workers (control group) were studied for liver function test and hematologic profile. DNA was extracted from all participants. Using RFLP-PCR, the extracted DNA samples were studied for polymorphism in NQO1.Results: Those who were exposed to sour gas had a higher leukocyte count and lower red cell count than those who were exposed to sweet gas. Hematologic profile was significantly altered in those with NQO1 polymorphism who were exposed to sour than sweet gas. Serum AST and ALT had significantly higher activities in those who were exposed to sour than sweet gas.Conclusions: NQO1 polymorphism and exposure to H2S have important effects on hematologic profile.

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