Journal Paper

Paper Information

Journal:
Year:0 | Volume: | Issue:
Start Page: | End Page:

video

sound

Persian Version

View:

23,312

Download:

12,076

Cites:

1

Information Journal Paper

Title

AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE

Pages

 Start Page 109 | End Page 115

Abstract

 BACKGROUND: There is no convenient cheap pragmatic EXPERIMENTAL MODEL for NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) /Nonalcoholic Steatohepatitis (NASH). Objective: Our objective was to create a pragmatic model of NAFLD/NASH.METHODS: Sprague-Dawley RATs were fed a high-fat, high sugar homemade DIET ad libitum for seven weeks. The high-fat, high sugar DIET included 59% of energy derived from fat, 30% from carbohydrates, and 11% from protein. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin, and hepatic tumor necrosis factor-alpha (TNF-a) gene expression were determined. Hepatic histology was examined by H & E stain.RESULTS: RATs fed the high-fat, high sugar DIET developed hepatic steatosis, and a moderate inflammation, which was associated with increased serum levels of liver enzymes, glucose, insulin, triglyceride, cholesterol, and hepatic TNF-a gene expression.CONCLUSION: This RAT model resembles the key features of human NAFLD/NASH and provides a simple pragmatic EXPERIMENTAL MODEL for elucidating the disease prevention and treatment.

Cites

References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops