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Title

PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRIBULUS TERRESTRIS ON CISPLATIN INDUCED RENAL TISSUE DAMAGE IN MALE MICE

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Abstract

 Background: According beneficial effects of TRIBULUS TERRESTRIS (TT) extract on tissue damage, the present study investigated the influence of hydroalcoholic extract of TT plant on CISPLATIN (CIS) (EBEWE Pharma, Unterach, Austria) induced renal tissue damage in male MICE.Methods: Thirty MICE were divided into five groups (n=6). The first group (control) was treated with normal saline (0.9% NaCl) and experimental groups with CIS (E1), CIS + 100 mg/ kg extract of TT (E2), CIS + 300 mg/kg extract of TT (E3), CIS + 500 mg/kg extract of TT (E4) intraperitoneally. The kidneys were removed after 4 days of injections, and histological evaluations were performed.Results: The data were analyzed using one‑way analysis of variance followed by Tukey’s post‑hoc test, paired‑sample t‑test, Kruskal–Wallis and Mann–Whitney tests. In the CIS treated group, the whole kidney tissue showed an increased dilatation of Bowman’s capsule, medullar congestion, and dilatation of collecting tubules and a decreased in the body weight and kidney weight. These parameters reached to the normal range after administration of fruit extracts of TT for 4 days.Conclusions: The results suggested that the oral administration of TT fruit extract at dose 100, 300 and 500 mg/kg body weight provided protection against the CIS induced toxicity in the MICE.

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