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Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder


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 Background: Patients with mixed Anxiety-Depressive Disorder (MADD) suffer both Anxiety and depression. Antidepressants, especially, selective serotonin reuptake inhibitors are among agents of choice for treating this condition. Objectives: This study compared the efficacy of Cipram® with its generic, Citalopram. Patients and Methods: Forty adult outpatients (between 18 to 55 years of age) with a diagnosis of MADD who met the trial criteria, entered this double-blind, randomized study. Subjects were assigned to receive either generic Citalopram or Cipram® for 8 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were utilized to assess depression and Anxiety at baseline, weeks 4 and 8 of the study. Statistical analysis was performed using SPSS 14. 0. Results: Twenty patients received Citalopram (mean dosages of 22 mg/day during the first 4 weeks and 33 mg/day during weeks 4 to 8) and 20 received Cipram® (mean dosages of 22 mg/day during the first 4 weeks and 29 mg/day during weeks 4 to 8). Both treatments were noted to be effective in improving the symptoms of MADD at weeks 4 and 8. The mean differences of HAM-D and HAM-A between Citalopram and Cipram® groups were significantly different at the end of week 4 (HAM-D: P = 0. 038, HAM-A: P = 0. 025), but not at the end of week 8 (HAM-D: P = 0. 239, HAM-A: P = 0. 204). Both medications were tolerated well by the patients. Conclusions: This study suggests that the efficacy of Citalopram is similar to that of Cipram® in the treatment of MADD after 8 weeks. Meanwhile, Cipram® may reduce depression and Anxiety quicker than its generic, Citalopram.


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