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Title

UROLITHIASIS IN THE FIRST 2 MONTHS OF LIFE

Writers

NASERI MITRA

Pages

 Start Page 379 | End Page 385

Abstract

 Introduction: There is limited data about UROLITHIASIS in young INFANTs. We reviewed clinical, imaging, and biochemical data of UROLITHIASIS in the first 2 months of life.Materials and Methods: In an 11-year period, 77 of the 1172 children diagnosed with UROLITHIASIS (6.8%) were 60 days old and younger (64.9% boys and 35.1% girls). Routine diagnostic assessments included urinalysis and urine culture; measurement of calcium, uric acid, oxalate, and creatinine in nonfasting random urine; measurement of blood urea nitrogen and serum creatinine, sodium, potassium, calcium, and phosphorus levels; and venous blood gasometry. Urinary calculi were diagnosed using tridimensional ultrasonography with 5-MHz, 7.5-Mhz, and 10-MHz probes.Results: The most common symptom was irritability (37.6%). A family history of urinary calculi was documented in 49.4% of the patients. The calculi were 0.5 mm to 6 mm in length. Eight INFANTs (10.4%) had urinary tract infection. HYPERCALCIURIA was found in 21 of 62 patients (33.8%). There were no cases of hyperuricosuria, hyperoxaluria, or struvite calculus. VESICOURETERAL REFLUX was reported in 9 of 20 patients who underwent voiding cystourethrography.Two-thirds of asymptomatic and 85% of symptomatic INFANTs were diagnosed during summer and autumn, and the peaks of calculus visits were in September, October, and November. Of 43 INFANTs (55.8%) who were followed up (Mean, 16.2 ± 15.2 months), none needed calculus removal interventions.Conclusions: HYPERCALCIURIA is the most common urinary metabolic abnormality in young INFANTs with urinary calculus. Infection was not an important factor for our cohort in the pathogenesis of the disease.

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