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Title

RITUXIMAB IN STEROID-DEPENDENT NEPHROTIC SYNDROME

Writers

KOUMI MOHAMED EL.

Pages

 Start Page 502 | End Page 506

Abstract

 Treatment of steroid-dependent nephrotic syndrome, particularly in patients who have failed to respond to multiple immunosuppressive drugs, remains challenging. RITUXIMAB represents a new off-label therapeutic option. Here, we report the use of RITUXIMAB in 7 children with steroid-dependent nephrotic syndrome with various histological backgrounds who failed to maintain remission with other IMMUNOSUPPRESSION regimens. All patients received RITUXIMAB infusion, 750 mg/m2 in 2 doses, 2 weeks apart, and the subsequent doses were adjusted by clinical response. In all patients, complete B-cell depletion was observed after the first course of RITUXIMAB. Follow-up for at least 12 months showed sustained remission in 6 children. We conclude that RITUXIMAB can reduce the risk of relapses, reduce the burden of IMMUNOSUPPRESSION, and at least, offer a better control of steroid-dependent nephrotic syndrome with minimal doses of immunosuppressive agents and steroids.

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