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Title

EARLY GRAFT FUNCTIONS AND GRAFT SURVIVAL FOLLOWING RENAL TRANSPLANTATION IN CHILDREN

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 Start Page 18 | End Page 18

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Abstract

 Introduction: The outcome of renal transplantation in children has improved over the last several decades. The aim of this study was to report our experience of pediatric renal transplantation in Imam Reza Hospital Kidney Transplantation Unit (Mashhad University of Medical Sciences) during 2002 to 2010.Methods: A total of 60 living-related donor (LRD) and 39 deceased-related donor (DRD) transplants were performed during the period. The parameters studied included initial graft function and graft survival. For initial graft function, we defined four groups of recipients: immediate graft function (IGF), slow graft function (SGF), delayed graft function (DGF) and primary nonfunctioning (PNF). Overall 1 and 5-year rates were calculated using the Kaplan–Meier method. The log-Rank test was used to determine the statistical differences of graft survival between different variables.Results: Of the 60 recipients who received kidney from LRD donors, IGF was seen in 54 (90%), SGF in 3(5%), DGF in 1 (1.7%), PNF in 2 (3.3%) patients, and of the 39 DRD recipients. IGF was seen in 34 (89.5%), SGF in 1 (2.6%), DGF in 2 (5.3%), and PNF in 1 (2.6%) patients. One- and 5-year graft survival for LRD were 89% and 85% and for DRD were 89% and 85% respectively (P = 0.534). Although graft survival was slightly better in recipients who received kidney from LRD donors, there were no significant differences in 1, and 5 years graft survival between two groups.Conclusions: We conclude that outcome of LRD and LURD is comparable in terms of initial graft function and 1- and 5-year graft survival following renal transplantation in children.

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