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Title

CAUSE OF PRIMARY NEPHROTIC SYNDROME IN ADULT PATIENTS IN KHUZESTAN PROVINCE (POSTER PRESENTATIONS: P314)

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 Start Page 75 | End Page 75

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Abstract

 Introduction. The glomerular diseases that cause nephrotic syndrome can generally be divided into primary and secondary etiologies. Primary nephritic syndrome (PNS) is associated with glomerular diseases intrinsic to kidney and not related to systemic causes. The subcategories of PNS are based on histological descriptions and aim of this study is to determine the clinical manifestationS and prevalence of its causes.Methods. In a prospective study, we evaluated all patients with primary nephrotic syndrome who HAD referred to Imam Khomeini hospital of Ahvaz between January 1998 and August 2009. We also performed kidney biopsy for them and the specimens were investigated by light microscope.Results. Ninety-two patients (53 males and 39 females, mean age, 42 ± 18 years) were included. Mean serum creatinine and a median rate of urinary protein excretion were 1.47 mg/dl and 5250 mg/day, respectively. The most common histological finding was focal and segmental glomerular sclerosis (FSGS; 28 patients, 30.43%), followed by membranous glomerulonephritis (MGN; 24 patients, 26.08%), minimal change disease (MCD; 12 patients, 13.04%), membranoproliferative glomerulonephritis (MPGN; 10 patients, 10.86%), IgA nephropathy (8 patients, 8.69%), focal and segmental glomerulonephritis (FSGN; 4patients, 4.34%), mesangial proliferative glomerulonephritis (3patients, 3.26%), and diffuse proliferative glomerulonephritis (3 patients 3.26%). Male to female ratio in MGN, MCD, and IgA nephropathy was 3 to1, and 2 to 1 in MPGN and FSGS. Conclusion. FSGS is the most common and MGN is the second cause of primary nephrotic syndrome in adult patients in Khuzestan province.

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