Journal Paper

Paper Information

Journal:
Year:0 | Volume: | Issue:
Start Page: | End Page:

video

sound

Persian Version

View:

16,510

Download:

14,329

Cites:

Information Journal Paper

Title

SERUM LEVELS OF ANNEXIN A2 AS A CANDIDATE BIOMARKER FOR HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B

Pages

 Start Page 0 | End Page 0

Abstract

 Background: Hepatologists have studied serologic markers of liver injury for decades. Annexins are a prominent group of such markers and ANNEXIN A2 (AnxA2) is one of the best characterized annexins. AnxA2 inhibits HBV polymerase among other functions. Its expression is up-regulated in regenerative hepatocytes.Objectives: To determine if serum AnxA2 level has a role in estimating liver damage in CHRONIC HBV infection and investigate whether AnxA2 levels correlate with hepatic fibrosis.Patients and Methods: This study included 173 patients with CHRONIC HEPATITIS B (CHB) and 51 healthy controls. LIVER FIBROSIS was graded histologically on liver biopsy samples. Blood samples were taken from patients during biopsy and serum AnxA2 levels were measured with ELISA.Results: In a group of adult patients with CHB, AnxA2 values were far higher than those of the control group (P = 0.001). When we assessed AnxA2 levels based on fibrosis stages, serum AnxA2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; P = 0.001).Conclusions: AnxA2 is a useful biomarker for early stage fibrosis in patients with CHB.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops