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Title

NO CORRELATION BETWEEN INTERLEUKIN-10 GENE PROMOTER POLYMORPHISMS AND HEPATITIS B VIRUS INFECTION OUTCOME

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Abstract

 Background: Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining HEPATITIS B VIRUS (HBV) outcome.Objectives: This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter.Patients and Methods: Ninety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. Three biallelic (-819, -592, -1082) regions in the IL-10 gene promoter were sequenced for all patients. Results: GENOTYPEs and HAPLOTYPES of IL-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, HBV recovered cases, carriers and chronic HBV patients. Nevertheless, A/A GENOTYPE at position -592 and T/T GENOTYPE at position -819 were more frequently seen in the HBV clearance group, while frequency of G/G GENOTYPE at position -1082 was more prevalent in the persistence group. GCC/GCC and GCC/ACC HAPLOTYPES were significantly observed in anti-HBe positive individuals.Conclusions: Our findings showed that IL-10 promoter polymorphisms were not correlated with HBV infection prognosis. Nevertheless, individuals carrying high and intermediate producer of IL-10 HAPLOTYPES had a better ability to develop anti-HBe than low producer carriers.

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