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Title

HEPATITIS C AND HEPATITIS B SEROPREVALENCE AND ASSOCIATED RISK FACTORS IN HEMODIALYSIS PATIENTS IN GUILAN PROVINCE, NORTH OF IRAN

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 Start Page 178 | End Page 181

Abstract

 Background: HEPATITIS C virus (HCV) and HEPATITIS B virus (HBV) infection are especially prob­lematic in patients with end-stage renal disease who are undergoing HEMODIALYSIS (HD). Objectives: To determine the prevalence of HCV and HBV infection in HD population in Guilan, north of Iran. Patients and Methods: In a cross-sectional study, from May to September 2009, in 11 different HEMODIALYSIS units in Guilan province, North of Iran, clinical data such as age, gender, duration of dialysis, HBsAg and anti-HCV antibody of 514 HD patients were recorded. Patients with positive antibodies against HCV were tested for HCV RNA. Results: From 514 patients, 286 (55.64%) were male. 61 (11.9%) patients were anti-HCV-positive and 31 (50.8%) were HCV PCR-positive. There was significant relationship between HCV Ab-positivity with gender and HD duration (p < 0.05). There was significant difference between the mean HD duration in anti-HCV-positive and anti-HCV-negative patients (p < 0.05). Also, significant relationship was found between HCV RNA-positivity with gender and HD duration (p < 0.05). Seven (1.4%) patients were positive for HBsAg. Two (0.38 %) were found positive for both HBsAg and anti-HCV antibody. Conclusions: There is low a prevalence of HCV and HBV in HD patients in our region. The rate can be decreased by HBV vaccination of end-stage renal disease patients before setting chronic HD, antiviral treatment and isolation of infected individuals. 

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