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Title

THE EFFECT OF NON-STEROIDAL DRUG IN MALE RATS’ FERTILITY (AN EXPERIMENTAL DESIGN)

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 Start Page 58 | End Page 58

Abstract

 Background: COX-2 selective inhibitor is a form of nonsteroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain, It is the main feature of celecoxib, In some patients that used celecoxib for a long time, unusual effect of this drug may be seen. The goal of this survey is assess the effect celecoxib on male-reproductive system functions.Materials and Methods: In This experimental survey, we study on the effect of celecoxib on rat reproductive system, on spermatogenesis and the level of blood TESTOSTERONE HORMONE. Histological studies and measuring of weight (testis, prostate, seminal vesicle and epidydimis) and the level of blood testestron are done.50 rat with 200-230 g. weight selected and compared in 5 groups. Control group (no drug given), sham group (solvent drug: Di- methyl sulfoxide), 3 cases group (orally celecoxib 10, 20 and 40 mg/kg given daily) for 15 days. In the end of 15 days heart blood sampling for measuring serum testosterone level accomplished after that reproductive systems separated and prepared for histological study.Results: Result showed sertoli cells in control and case groups are differences. So that in case group (40 mg/ kg) number of sertoli cells decreased due to decrease testestron level. This can cause production of abnormal sperms. significant differences are seen in the mean weight of prostate per body weight in case group (40 mg/kg) in compared with control group.Conclusion: Use of high doses of celecoxib can decreased size and number of lydig cells and this is cause of decreased TESTOSTERONE HORMONE.

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