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Information Journal Paper

Title

FEMALE INFERTILITY: DIFFERENT REGIMENS FOR ENDOMETRIAL PREPARATION

Author(s)

GHAFFARI F.

Pages

  15-15

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Abstract

 Freezed embryo transfer increases the cumulative pregnancy rate, reduces costs, is relatively simple to undertake and can be accomplished in a shorter time period compared to repeated Fresh cycle. There are different protocols for endometrial preparation. Although frozen embryo replacement cycles, have been used for several years, there is no agreement about the optimal way to prepare the endometrium prior to and immediately following embryo transfer. There is insufficient evidence to support the use of any particular intervention in endometrial preparation that clearly improves treatment outcomes. The use of GnRh agonists was not found to be more effective than treatments, where no GnRh agonist were used, and no differences were found among the various agonists. Vaginal progesterone did not show different results to intramuscular progesterone. There is evidence of a lower pregnancy rate and higher cancelation rate in fresh oocytes donation cycles, when commencing progesterone prior to oocyte retrieval. One trial showed higher pregnancy rates when using natural cycle in comparison to artificial cycle and no evidence of clinical benefit was found with the other medications, such as corticosteroids and aspirin.

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