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Title

EFFICACY AND SAFETY OF LAMOTRIGINE IN LENNOX - GASTAUT SYNDROME

Pages

 Start Page 33 | End Page 38

Keywords

LENNOX-GASTAUT SYNDROME (LGS) 

Abstract

 Objective: The Lennox-Gastaut syndrome (LGS), one of the most difficult EPILEPSY syndromes to treat, is characterized by a triad of intractable seizures of various types, a slow (< 2.5-hertz) spike-wave pattern in EEG and mental retardation. The aim of this study was to evaluate the efficacy and safety of LAMOTRIGINE as add-on therapy in intractable EPILEPSY of children with LGS.Materials & Methods: In a quasi- experimental study, 40 children with LGS referred to the pediatric neurology clinic of Shaheed Sadoughi Hospital in Yazd, between August 2007 and to November 2008, were evaluated. Results: Twenty-two boys and 18 girls with a mean age of 4.12±1.8 years were evaluated. At the end of three months of treatment with LAMOTRIGINE, 12 % were seizure free, 52% had> 50% reduction in seizure frequency and 12% had increase in seizures. Means of seizure frequency/per week, before and after treatment were 70 (range 1-180) and 18.6 (range 0-60) respectively, indicating effectiveness of the drug in seizure reduction (P value = 0.003). The drug was effective in 72 % of mixed type seizures, 40 % of generalized tonic-clonic and 33% of drop attack and tonic seizures. Transient side effects were seen in 12.5 % (drowsiness in 3 and ataxia in 2 children). No serious side effects were seen. Conclusion: LAMOTRIGINE should be considered as an add-on therapy in management of intractable EPILEPSY in LGS.

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