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Information Journal Paper

Title

MEASUREMENT AND CORRELATION OF IBUPROFEN IN SUPERCRITICAL CARBON DIOXIDE USING STRYJEK AND VERA EOS

Pages

  42-49

Abstract

IBUPROFEN SOLUBILITY in SUPERCRITICAL CARBON DIOXIDE was measured using a dynamic apparatus at a pressure between 80 and 140 bars at three different temperatures, 308.15, 313.15 and 318.15 K. The mole fraction of Ibuprofen in fluid phase was in the range of 0.015 × 10-3 - 3.261 × 10-3 at the mentioned operational condition. Modified MENDEZ-SANTIAGO AND TEJA EQUATION were used to check the consistency of the experimental data. Results were correlated using the Stryjek and Vera equation of state with the van der Waals 1-parameter (vdW1) and 2-parameters (vdW2) mixing and combining rules. Interaction parameters along with the percentage of the average absolute relative deviation (%AARD) were displayed. Also, the Lydersen group contribution methods were used for predicting the physicochemical and critical properties of the Ibuprofen.

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