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Title

EFFECT OF OLANZAPINE ON THE CONCENTRATION OF TESTOSTRONE, FSH, LH HORMONES AND HISTOLOGICAL TESTIS CHANGES IN RAT

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SHARIATI M. | TAYEBI D.

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Abstract

 Introduction: OLANZAPINE is a selective serotonin re-uptake inhibitor. This is important in the treatment of obsessive compulsive disorder, bulimia, panic and depression.Materials and Methods: 50 Wistar male adult RATs, used in this study, were divided into 5 groups of ten. They included control, sham and experimental groups. The control group had no drug. The sham group received 0.2 ml of destilled water as a solvent. The experimental groups received 5, 10, 15 (mg/kg) drug daily for 21 days intraperitoneally. After 21st day, blood samples were taken from the animal hearts to assay the serum concentration of LH, FSH and TESTOSTERONE hormones, the TESTIS were taken out and sliced for tissue preparation.Results: The results were evaluated through ANOVA, Tukey, Duncan and t-test. The result showed that serum concentration of LH, FSH and spermatogenesis chain in experimental group did not show significant difference as compared with control group, but OLANZAPINE at high dose decreased serum concentration of TESTOSTERONE.Conclusion: Approximately, OLANZAPINE caused the reduction of the testes function for the TESTOSTERONE secretion through the reduction of sensitivity of LH receptors in the leydig cells. In addition, through the increase of prolactin, melatonin and serotonin secretion, OLANZAPINE probably caused the inhibition of enzymes of steroid synthesis, which led to the decrease in TESTOSTERONE synthesis. The results showed that after 21 days, OLANZAPINE didn't have any significant effect on the spermatogenetic chain and compaction of sertoli and leydig cells.

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