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Title

Association of Matrix Metalloproteinase-1-1607 1G/2G and C-Reactive Protein-717 C/T Gene Polymorphisms in Iranian Patients with Chronic Periodontitis: A Clinical Trial

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Abstract

 Background: Animbalance in the expression of Matrix metalloproteinases (MMPs) and tissue inhibitor metalloproteinases initiate the destructive process in Chronic Periodontitis (CP). C-Reactive Protein (CRP) is a systemic inflammatory mediator that reflects an acute immune response. Objectives: The purpose of this investigation was to analyze the association between the MMP-1-1607 1G/2G (rs1799750) and CRP 717 A/G (rs2794521) gene Polymorphisms and Chronic Periodontitis in Iran. Methods: This analytical case-control study was performed among 141 participants including 63 CP cases and 78 matched healthy individuals. Five milliliters of peripheral blood was collected for DNA isolation. Restriction fragment length Polymorphism-polymerase chain reaction (RFLP-PCR)was performed for single-nucleotide Polymorphism (SNP) analysis. The frequencies were analyzed by chi-squared test (95% CI, P < 0. 05). In addition, genetic data were assessed by the Hardy-Weinberg principle, linkage disequilibrium, and haplotype analysis. Results: Our findings presented no significant relationship between genotype/alleles of MMP-1-1607 1G/2G (rs1799750) (0. 73: 0. 27-1. 95, P = 0. 48) or CRP 717 A/G (rs2794521) (0. 384: 0. 104-1. 414, P = 0. 303) and the presence of CP (P = 0. 47 and P = 0. 30, respectively). The analysis of genetic distribution among various severities of CP and controls revealed no significant association between various severities of CP and MMP-1-1607 1G/2G (rs1799750) (P = 0. 52) and CRP 717 A/G (rs2794521) (P = 0. 67). Conclusions: Our results suggest no association between the occurrence or severity of Chronic Periodontitis and MMP-1-1607 1G/2G (rs1799750) and CRP 717 A/G (rs2794521) Polymorphisms. Further studies with larger sample sizes may provide a more generalizable evidence-based overview of the relationship between these gene Polymorphisms and periodontitis.

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