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Title

EFFICACY AND SAFETY OF DIFFERENT DOSAGES OF PRAZIQUANTEL FOR THE TREATMENT OF SCHISTOSOMA JAPONICUM: A SYSTEMATIC REVIEW AND META-ANALYSIS

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Abstract

 Background: PRAZIQUANTEL, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. In this article, we conducted a systematic review and mete-analysis to evaluate the efficacy and safety of different dosages of PRAZIQUANTEL (PZQ) for treatment of Schistosoma japonicum.Evidence Acquisition: A number of six articles published in peer-reviewed journals before December 2012 were selected for analysis after searching the following literature databases: PubMed/Medline, the Chinese WanFang Literature Database, China National Knowledge Infrastructure (1994-2012.12), and the Chinese Biomedical Literature (1978-2012.12).Results: The meta-analyses showed that there is no statistically significant difference of the negative rate on the egg using 40 mg/kg compared to 60 mg/kg PZQ for S. japonicum treatment (RR 0.79, 95% CI 0.46 1.35; P<0.39). The META-ANALYSIS showed that there is no statistically significant difference of the side effects using 30 mg/kg compared with 40 mg/kg (RR 0.97, 95% CI 0.68 1.38; P=0.87), 40 mg/kg compared with 60 mg/kg (RR 0.79, 95% CI 0.46 1.35; P=0.39) and 50 mg/kg compared with 60 mg/kg (RR 0.89, 95% CI 0.56 1.42; P=0.63).Conclusions: According to the results, there is no statistically significant difference in different doses of PZQ for treating S. japonicum.

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