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Title

ANTIHYPERGLYCEMIC EFFECT OF ROSA DAMASCENA IS MEDIATED BY PPAR. γ GENE EXPRESSION IN ANIMAL MODEL OF INSULIN RESISTANCE

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 Start Page 1080 | End Page 1088

Abstract

 Insulin resistance is a condition in which insulin signaling and action are impaired in insulinsensitive tissues and result in hyperglycemia, hyperlipidemia, and type 2 diabetes mellitus. Ourprevious studies have shown that Rosa damascena has antihyperglycemic effects on diabeticand normal rats. Therefore, we conducted a study to evaluate the effect of this medicinal planton insulin sensitivity in rats. This study was performed on high fructose diet insulin resistant ratsand pioglitazone, an insulin sensitizing drug, was used as a positive control. Insulin resistancewas developed in animals by high fructose diet within six weeks. Then, Rosa damascena extractand pioglitazone were administered by gavage for two weeks and results were compared withtwo control groups. After treatment period, serum glucose, insulin, adiponectin, triglyceride, and cholesterol were assayed in fasting state. Plasma free fatty acid profile was analyzed byGC. Liver PPAR. γ and muscle GLUT. 4 gene expressions were assessed by real time PCR andwestern blotting. Animals were treated with rosa damascena extract showed levels of insulin(42 ± 2. 7 pmol/L). adiponectin (5. 6± 0. 17 μ g/mL). glucose (129± 4. 7 mg/dL). and triglyceride(75 ± 9 mg/dl) which were significantly improved as compared with control group insulin(137 ± 34 pmol/L), adiponectin (3. 9± 0. 15 μ g/mL). glucose (187± 15 mg/dL). and triglycerides(217± 18 mg/dL). PPARγ protein level was also significantly increased in Rosa damascenetreated group. Our results demonstrated that rosa damascena extract has useful effects oninsulin resistant animals and by increasing insulin sensitivity can be considered as a potentialagent in control of diabetes.

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