Journal Paper

Paper Information

Journal:
Year:0 | Volume: | Issue:
Start Page: | End Page:

video

sound

Persian Version

View:

14,266

Download:

10,769

Cites:

Information Journal Paper

Title

EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS

Pages

 Start Page 924 | End Page 928

Abstract

 Because of expanding resistance to efficient and affordable antimalarial drugs like chloroquine, the search is continuing for more effective drugs against this disease. In-vitro antiplasmodial activity and CYTOTOXICITY of a- (acyloxy) -a- (quinolin-4-yl) acetamides on PLASMODIUM FALCIPARUM and structure-activity relationships of this new class of Passerini adducts is described. The in-vitro antiplasmodial activity of compounds was tested against chloroquine sensitive 3D7 STRAIN. Toxicity of active compounds was investigated on HEPG2 cell line. Compounds 1, 20 and 22 showed significant antiplasmodial activity with IC50 value of 1.511, 1.373 and 1.325 μM, respectively. The active compounds did not show noticeable toxicity when tested against HEPG2 cell line. The present results bring essential elements which will be used for the synthesis of more active derivatives of a- (acyloxy) -a - (quinolin-4-yl) acetamides.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops