video

sound

Persian Version

View:

57,245

Download:

26,672

Cites:

Information Journal Paper

Title

RADIATION AND CADMIUM INDUCED BIOCHEMICAL ALTERATIONS IN MOUSE KIDNEY

Pages

  125-130

Keywords

Abstract

 Background: In the present investigation RADIATION and CADMIUM induced biochemical changes in the KIDNEY of Swiss albino MICE have been studied. Materials and Methods: For this purpose, adult male Swiss albino MICE (6-8 weeks old) were divided into four groups. Group I (sham-irradiated), Group II (treated with CdCl2 solution 20 ppm), Group III (irradiated with 1.25, 2.5 and 5.0 Gy gamma rays), Group IV (both irradiated with 1.25, 2.5 and 5.0 Gy gamma rays and treated with CdCl2 solution). The animals were autopsied after 1, 2, 4, 7, 14 and 28 days of treatment. The KIDNEY was taken out and different biochemical parameters, such as total proteins, glycogen, cholesterol, acid phosphatase activity, alkaline phosphatase activity, DNA and RNA were estimated. Results: In irradiated animals, the values of total proteins, glycogen, acid phosphatase, alkaline phosphatase activity and RNA increased continuously up to day-7 and decreased thereafter up to day-28. The changes were dose dependent. In CdCl2 treated animals, the values of glycogen and total proteins decreased during the early intervals and increased thereafter whereas the values of acid and alkaline phosphatase activity and RNA increased during early intervals and decreased thereafter. The values of cholesterol and DNA showed decrease in all the experimental groups (except group I) up to day-7 and increase thereafter up to day-28. After combined treatment also, the parameters followed the same pattern of increase and decrease, but the changes were more pronounced indicating their synergistic effect. The biochemical parameters showed highly significant values (P<0.001) as compared to normal ones.Conclusion: These results indicate that combined treatment of CADMIUM and gamma RADIATIONs causes synergistic or additive effect.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    PUROHIT, P.K., CHAKRAWARTI, A., & BHARTIYA, K.M.. (2007). RADIATION AND CADMIUM INDUCED BIOCHEMICAL ALTERATIONS IN MOUSE KIDNEY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 5(3), 125-130. SID. https://sid.ir/paper/286428/en

    Vancouver: Copy

    PUROHIT P.K., CHAKRAWARTI A., BHARTIYA K.M.. RADIATION AND CADMIUM INDUCED BIOCHEMICAL ALTERATIONS IN MOUSE KIDNEY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2007;5(3):125-130. Available from: https://sid.ir/paper/286428/en

    IEEE: Copy

    P.K. PUROHIT, A. CHAKRAWARTI, and K.M. BHARTIYA, “RADIATION AND CADMIUM INDUCED BIOCHEMICAL ALTERATIONS IN MOUSE KIDNEY,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 5, no. 3, pp. 125–130, 2007, [Online]. Available: https://sid.ir/paper/286428/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops