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Title

DIFFUSIONWEIGHTED IMAGING IN ACUTE ATTACKS OF MULTIPLE SCLEROSIS

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Abstract

 Background: MULTIPLE SCLEROSIS (MS) is one of the most common autoimmune disorders of the central nervous system. In spite of various imaging modalities, the definitive diagnosis of MS remains challenging.Objectives: This study was designed to evaluate the usefulness of diffusion weighted imaging (DWI) in the diagnosis of acute MS attack and to compare its results with contrast enhanced MRI (CE-MRI).Patients and Methods: In this cross sectional study, seventy patients with definite diagnosis of relapsing-remitting MS were included.CE-MRI using 0.1 mmol/kg gadolinium as well as DWI sequences were performed for all patients. The percentage of patients with positive DWI was compared with the results of CE-MRI and the consistency between the two imaging modalities was evaluated.Moreover, the relationship between the time of onset of patient’s symptoms and test results for both methods were investigated.Results: CE-MRI yielded positive results for 61 (87%) patients and DWI yielded positive for 53 (76%) patients. In fifty patients (71.42%), both tests were positive and in six cases (8.57%), both were negative. The test results of three patients turned out to be positive in DWI, while they tested negative in CE-MRI. There was no significant relationship between the results of CE-MRI as well as DWI and the time of imaging from the onset of symptoms.Conclusion: These data indicate that while CE-MRI will depictmorepositive results, there are cases inwhichDWI willshowa positive result while CE-MRI is negative.We suggest that the combination of these two imaging modalities might yield more positive results in diagnosing acute MS attack giving rise to a more accurate diagnosis.

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