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Information Journal Paper

Title

ZN(OAC)2 CATALYZED MICROWAVE IRRADIATED SYNTHESIS OF SUBSTITUTED THIENO[2, 3-D]PYRIMIDIN-4(3H)-ONE

Author(s)

JING X. | LI Z. | WU L. | YAN C.

Pages

  107-114

Abstract

 Different Lewis acids were screened to CATALYZE the reaction of 2-amino-thiophene-3-carboxylate, orthoformate and aryl amine to form 2-substituted thieno [2, 3-d] pyrimidin-4 (3H) -one. Zn (OAc)2 was demonstrated to efficiently CATALYZE the reaction. 20 substituted thieno [2, 3-d] pyrimidines were synthesized by adding 0.5% mol Zn (OAc)2 as catalyst under MICROWAVE IRRADIATION.

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