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Title

PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA)

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 Start Page 426 | End Page 429

Abstract

 BACKGROUND: This study was designed to evaluate PLATELET TRANSFUSION outcome via flow cytometric monocyte phagocytic assay (FMPA).METHODS: Fifteen patients with a history of multiple PLATELET TRANSFUSIONs and fifteen controls were enrolled in this study. CMFDA-labeled platelets were incubated with patients' sera and were finally incubated with monocytes in a tube and analyzed by FLOW CYTOMETRY. Monocytes that phagocytosed platelets were detected as a CMFDA-positive platelet population via monocyte gate. The FMPA results were compared with CCI results for the patients.RESULTS: The FMPA result correlated with 1-hour (r=-0.885, P=0.001) and 24-hour (r=-0.884, P=0.001) CCI. There is a significant difference in means of FMPA results between the patients with immune platelet refractoriness (68.46±10.4%), non-refractory group (37.73±15.21%) and the control group (18.27±2.86%). CONCLUSION: Our data showed that FMPA has good results in evaluation of PLATELET TRANSFUSION outcome and may be useful as an indicator of PLATELET TRANSFUSION response.

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