MANAGEMENT OF ACQUIRED THROMBOPHILIC DISORDERS IN 2011: FOCUS ON HEPARIN-INDUCED THROMBOCYTOPENIA, ANTIPHOSPHOLIPID SYNDROME, MYELOPROLIFERATIVE NEOPLASMS AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

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EMADI ASHKAN; STREIFF MICHAEL

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2011 | Volume:14 | Issue:6 Page(s): 401-411

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Title

MANAGEMENT OF ACQUIRED THROMBOPHILIC DISORDERS IN 2011: FOCUS ON HEPARIN-INDUCED THROMBOCYTOPENIA, ANTIPHOSPHOLIPID SYNDROME, MYELOPROLIFERATIVE NEOPLASMS AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Author(s)

EMADI ASHKAN | STREIFF MICHAEL | Issue Writer Certificate

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PNH

Abstract

Arterial and venous thrombosis are interrelated disorders at the interplay of platelets and brin. Arterial thrombi are platelet-rich and occur at sites vulnerable to atherosclerotic plaque rupture where blood shear rates are high; on the contrary, venous thrombi occur in association with slow blood FLow and shear rates. These differences may underlie why anti-platelet agents are more effective in prevention of arterial thrombosis, while anticoagulants are preferred for venous thrombosis. Although some common thrombophilic disorders (e.g., Factor V Leiden, prothrombin gene mutation, etc.) are almost exclusively associated with venous thromboembolism, there are several disorders that are important to consider when caring for patients with both arterial and venous thromboembolism. This article will review the evidence-based management of heparin induced thrombocytopenia with thrombosis, anti-phospholipid antibody syndrome and catastrophic anti-phospholipid antibody syndrome, thrombohemorrhagic manifestations of Philadelphia chromosome-negative chronic myeloproliferative neoplasms including polycythemia vera, essential thrombocythemia and primary myelobrosis, as well as paroxysmal nocturnal hemoglobinuria.

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APA: Copy

EMADI, ASHKAN, & STREIFF, MICHAEL. (2011). MANAGEMENT OF ACQUIRED THROMBOPHILIC DISORDERS IN 2011: FOCUS ON HEPARIN-INDUCED THROMBOCYTOPENIA, ANTIPHOSPHOLIPID SYNDROME, MYELOPROLIFERATIVE NEOPLASMS AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA. ARCHIVES OF IRANIAN MEDICINE, 14(6), 401-411. SID. https://sid.ir/paper/280795/en

Vancouver: Copy

EMADI ASHKAN, STREIFF MICHAEL. MANAGEMENT OF ACQUIRED THROMBOPHILIC DISORDERS IN 2011: FOCUS ON HEPARIN-INDUCED THROMBOCYTOPENIA, ANTIPHOSPHOLIPID SYNDROME, MYELOPROLIFERATIVE NEOPLASMS AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(6):401-411. Available from: https://sid.ir/paper/280795/en

IEEE: Copy

ASHKAN EMADI, and MICHAEL STREIFF, “MANAGEMENT OF ACQUIRED THROMBOPHILIC DISORDERS IN 2011: FOCUS ON HEPARIN-INDUCED THROMBOCYTOPENIA, ANTIPHOSPHOLIPID SYNDROME, MYELOPROLIFERATIVE NEOPLASMS AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 6, pp. 401–411, 2011, [Online]. Available: https://sid.ir/paper/280795/en

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