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Title

HYDROCORTISONE REDUCES TOLL-LIKE RECEPTOR 4 EXPRESSION ON PERIPHERAL CD14+ MONOCYTES IN PATIENTS UNDERGOING PERCUTANOUES CORONARY INTERVENTION

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 Start Page 76 | End Page 81

Abstract

 Background: Evidence from several lines of investigations suggests that TOLL-LIKE RECEPTOR 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. HYDROCORTISONE as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of action. In this study, we aimed at assessing the effects of HYDROCORTISONE on monocyte expression and activity of hTLR4 in patients underwent PCI.Methods: Blood samples were taken from a total of 71 patients with chronic stable angina who were scheduled for a PCI, before the intervention. Thirty patients received 100 mg HYDROCORTISONE prior to the procedure. Control group was composed of 41 patients underwent PCI without receiving HYDROCORTISONE. Blood collection was repeated 2 and 4 h after PCI. The expression of hTLR4 on the surface of CD14+ monocytes and the serum levels of TNF-a and IL-1b were measured using flowcytometry and Sandwich ELISA.Results: Compared with controls, HYDROCORTISONE significantly reduced monocyte expression of hTLR4 in test group (P<0.01). In addition, it had a significant effect on reduction of serum concentrations of TNF-a and IL-1bin test group in a time-dependent manner (P<0.01).Conclusion: In this study, HYDROCORTISONE was able to reduce the hTLR4/CD14 positive monocytes and its related pro-inflammatory CYTOKINES, thus it can decrease inflammatory responses following PCI.

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