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Information Journal Paper

Title

L-ARGININE SUPPLEMENTATION INFLUENCED NITRITE BUT NOT NITRATE AND TOTAL NITRITE IN RABBIT MODEL OF HYPERCHOLESTEROLEMIA

Pages

  179-184

Keywords

NITRIC OXIDE (NO) 

Abstract

 Background: The assessment of altered nitric oxide (NO) availability is of potentially important diagnostic and prognostic significance. The present study is aimed to investigate the effect of L-ARGININE (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production. Methods: White male rabbits (n = 30) randomly assigned to 2 groups. Rabbits were fed 1% high-cholesterol diet (HC group, n = 15), or HC diet with oral L-ARGININE (3% in drinking water) (HC + L-ARGININE group, n = 15) for 4 weeks. The serum levels of lipids, L-ARGININE, total NO metabolites (NOx), NITRITE and NITRATE were measured before and after the study. Results: In this study, Larginine supplementation led to a significant increased plasma level of L-ARGININE. The serum level of NITRITE was significantly higher in L-ARGININE treated group while serum level of NITRATE and NOx was significantly lower than HC group. Conclusion: As the result of our study showed, NITRITE is a useful marker of endogenous endothelial NO production and although frequently used, neither NITRATE nor NOx are reliable markers of acute changes in endothelial NO synthase activity.

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    APA: Copy

    HAGHJOUY JAVANMARD, SH., NEMATBAKHSH, MAHDI, & MONAJEMI, A.R.. (2008). L-ARGININE SUPPLEMENTATION INFLUENCED NITRITE BUT NOT NITRATE AND TOTAL NITRITE IN RABBIT MODEL OF HYPERCHOLESTEROLEMIA. IRANIAN BIOMEDICAL JOURNAL, 12(3), 179-184. SID. https://sid.ir/paper/277201/en

    Vancouver: Copy

    HAGHJOUY JAVANMARD SH., NEMATBAKHSH MAHDI, MONAJEMI A.R.. L-ARGININE SUPPLEMENTATION INFLUENCED NITRITE BUT NOT NITRATE AND TOTAL NITRITE IN RABBIT MODEL OF HYPERCHOLESTEROLEMIA. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2008;12(3):179-184. Available from: https://sid.ir/paper/277201/en

    IEEE: Copy

    SH. HAGHJOUY JAVANMARD, MAHDI NEMATBAKHSH, and A.R. MONAJEMI, “L-ARGININE SUPPLEMENTATION INFLUENCED NITRITE BUT NOT NITRATE AND TOTAL NITRITE IN RABBIT MODEL OF HYPERCHOLESTEROLEMIA,” IRANIAN BIOMEDICAL JOURNAL, vol. 12, no. 3, pp. 179–184, 2008, [Online]. Available: https://sid.ir/paper/277201/en

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