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Title

NO EVIDENCE OF HUMAN HERPESVIRUS 8 AMONG IRANIAN PATIENTS INFECTED WITH HIV

Writers

RAMEZANI AMITIS

Pages

 Start Page 935 | End Page 940

Keywords

HUMAN IMMUNODEFICIENCY VIRUS (HIV) 
HUMAN HERPESVIRUS 8 (HHV-8) 

Abstract

 Background: Kaposi’s sarcoma is a vascular malignancy, which frequently occurs among immunocompromised indi-viduals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi’s sarcoma. Though some seroepidemiological stud-ies conducted on the PREVALENCE of HHV-8 in IRAN, there are insufficient data on the PREVALENCE of HHV-8 VIREMIA in HIV infected patients. We therefore, aimed to determine the PREVALENCE of HHV-8 VIREMIA in general population and HIV infected patients without Kaposi’s sarcoma in Tehran, IRAN.Methods: We conducted a cross sectional survey on 99 patients with HIV infection referred to IRANian Research Cen-ter for HIV/AIDS and 40 healthy controls in Tehran, IRAN from January to April 2014. The presence of HHV-8 DNA was detected in buffy coat samples of enrolled subjects using nested PCR assay.Results: A total of 99 HIV infected patients with mean age of 37.9±10 yr and 40 healthy controls with mean age of 39±11.5 yr were enrolled in the study. The mean CD4 count was 410.3 ± 211.4 cells/mm3. HHV-8 DNA was not de-tected in both healthy control and HIV patient groups.Conclusion: This survey showed low rate of HHV-8 DNA in healthy controls and HIV patients. Considering our findings HHV-8 infection does not seem to be widespread in our population. Further studies focusing on different regions of IRAN appear to be required to have a more accurate estimation.

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