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Title

EFFECTS OF OMEGA-3 FATTY ACIDS SUPPLEMENT ON ANTIOXIDANT ENZYMES ACTIVITY IN TYPE 2 DIABETIC PATIENTS

Pages

 Start Page 340 | End Page 345

Abstract

 Background: Diabetes is a major cause of death. Oxidative stress mainly caused by hyperglycemia is the primary rea-son of related complications. Omega-3 fatty acids are prescribed in diabetes but the effect on antioxidant defense is controversial. This study investigated effects of OMEGA-3 SUPPLEMENTation on ANTIOXIDANT ENZYMES activity in type 2 diabetic patients.Methods: A randomized, placebo controlled, double blind clinical trial was performed on 90 type2 diabetic patients. The treatment group took, daily, three capsules of omega-3 for two mo, which totally provided 2714mg omega-3 (EPA=1548 mg, DHA=828 mg and 338 mg of other omega=3 fatty acids). Placebo contained 2100 mg sunflower oil (12% SFA, 65% linoleic acid, 23% MUFA), which is the main oil used in the study population. Food intakes, anthro-pometric and demographic characteristics, and therapeutic regimen data were recorded before and after the interven-tion. Fasting blood samples were taken before and after the intervention to measure super oxide dismutase, gluta-thione peroxidase, glutathione reductase, catalase and total antioxidant capacity in erythrocytes.Results: A total of 81 subjects completed the study. Two study groups were similar as regards duration of diabetes, age and the enzymes at baseline. Energy and macro- and micronutrients intakes, weight and hypoglycemic agent con-sumption were similar in the two groups at baseline and did not change. Supplementation had no effect on antioxidant enzyme status. Glycated hemoglobin showed a significant reduction by supplementation.Conclusion: Daily supplementation of 2714 mg mega-3 for two mo results in a significant reduction in HbA1c level in type2 diabetic patients with no effects on ANTIOXIDANT ENZYMES activity.

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