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Title

INTERLEUKIN-4 AND INTERFERON- γ LEVELS IN EPSTEIN-BARR VIRUS-ASSOCIATED INFECTIOUS MONONUCLEOSIS AND NASOPHARYNGEAL CARCINOMA

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 Start Page 94 | End Page 97

Abstract

 BACKGROUND: Cytokines have been suggested to participate in the pathogenesis of INFECTIOUS MONONUCLEOSIS (IM) and nasopharyngeal carcinoma (NPC).METHODS: Serum levels and gene expression of INTERLEUKIN-4 (IL-4) and interferon-g (IFN-g) were assessed by immunologic and PCR assays, respectively in patients with Epstein-Barr virus (EBV) -associated IM and NPC and EBV negative controls.RESULTS: The serum levels of IFN-g were elevated, but those of IL-4 were decreased in IM and NPC patients as compared with those of the control group (p < 0.05).CONCLUSIONS: These results suggest that serum levels of IFN-g may be predominant over those of IL-4 during the course of IM and NPC.

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