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Title

SURVEY OF ANTIBACTERIAL EFFECT OF METHANOLIC EXTRACT OF FULGENSIA FULGENS THROUGH IN VITRO AND IN VIVO CONDITIONS

Pages

 Start Page 15 | End Page 26

Abstract

 Introduction: Daily increasing of bacteria resistance (specially STAPHYLOCOCCUS AUREUS) to various antibiotics in particular penicillin and methicillin has always led the scientists to look for new medicines.Materials and methods: 600 g of Fulgensia fulgens was collected from KaneGonbad mountains in Ilam province, the METHANOL extract was prepared by soxhle. In vitro antimicrobial activity of the extract against two gram-positive bacteria (S. aureus and Entrococcus faecalis) and two gram-negative bacteria (Pseudomonas aeruginosa and Escherchia coli) was tested by the use of disc diffusion method and microdilution (with determination of MIC and MBC). WOUND was made on the dorsal surface of therat and WOUND infections caused by S.aureus for determination of in vivo antibacterial effect. Than RATs were randomly divided into three groups; control, treated with tetracycline ointment and treated with 10% ointment of F. fulgens extract. Finally, WOUND areas wear measured on days 3, 5, 7, 9 and 11.Results: Average inhibitory zone diameter of METHANOLic F. fulgens extract against S. aureus ranged between 11.21 mm to 33.01 mm. According to the WOUND area on 11th day, it could be concluded that there was a statistically significant difference between the control group (0.63 cm2) and two treatment groups (0) (p<0.05). There was no significant difference between a group treated with tetracycline ointment and a group treated with 10% ointment of extract.Discussion and conclusion: According to the results, the METHANOL extract of F. fulgens in the treatment of infections as S. aureus can be replaced by chemical antibiotics.

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