Journal Paper

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Journal: جنتاشاپیر
Year:1392 | Volume:4 | Issue:1
Start Page:1 | End Page:10

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Title

STUDY THE EFFECTS OF MALVA SYLVESTRIS HYDRO-ALCOHOLIC EXTRACT ON THECARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT PAW

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 Start Page 1 | End Page 10

Abstract

 Background: Using chemical drugs have often masses of damaged side effects Therefore, it is important to research about medicinal plants with anti-inflammation and fewer side effects. malvasylvestris has potential use as a medicinal plant. The aim of this study was to investigate the effect of MALVA SYLVESTRIS flowers hydroalcoholic extract on the CARRAGEENAN-induced inflammatory response using Wistar male RATs' paws. Methods: MALVA SYLVESTRIS flowers powder was macerated with 70%ethanol, and its extract prepared. Male Wistar RATs were divided into 6 groups of 10 animals each for following treatments: Malva extract (200, 400, 600 and 800 mg/kg), normal saline (5mg/kg) as negative control and ASPIRIN (300mg/kg) as a positive via IP. Thirty min later INFLAMMATION was induced by injection of 100μlcarrageenan (1%W/V) into the RAT's hind paw of RATs (SC). The inflamation response changes were inspected over 5 hours every hour, using plethysmometer.Results: The extract-treated (600, 800 mg/kg) showed considerable reduction in the RATs' paws inflamation when compared with control groop (p>0.05). But 200 and 400 mg/kg extract showed no considerable decrease in INFLAMMATION when comparied with control group (p<0.05). There was not significant differences between doses of 600 and 800 mg/kg of extract, therefore dose of 600 mg/kg was selected as the most favorable dose as anti-inflammation.Conclusion: These findings demonstrate that extract of M. sylvestis could accelerate reducing INFLAMMATION responses in RATs and supports its traditional and probably medicinal benefits use.

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