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Title

DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS

Pages

 Start Page 81 | End Page 88

Abstract

 Backgrounds and Objectives: This research is to develop new systems for drug release systems based on sol - gel systems. The objective of this study is to develop controlled release formulation of water insoluble OLANZAPINE (OZ), using GLYCEROL MONOOLEATE (GMO) and Polyethylene glycol (PEG 300).Materials and Methods: A Box- Behnken response surface methodology was applied to design gel system with 3 factors with an initial drug containing, weight ratio of GMO/water (w/w) and weight ratio of PEG 300/GMO (w/w).Results: Therefore, in this study Design-ExpertÒ software with Box- Behnken response surface methodology has been used specifically to determine the relationships between variables and responses.Discussion: According to the results of experiments, a quadratic model as an appropriate equation has been selected to fit the percentage of loading. Percentage of release at 12th and 168th hr a cubic model is selected. Kinetic release profile of OZ was investigated with several models, from which Higuchi model showed the best fitting and highest correlation.Conclusion: Optimization of gel system was carried out based on statistical concept of experimental design. Validation test was carried out under optimum conditions of the parameters predicted by the polynomial model.

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