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Title

THE HISTOPATHOLOGICAL EVALUATION OF SURGICAL WOUND CONTAMINATION FROM DISTANT INFECTIVE SOURCE IN RABBIT: AN EXPERIMENTAL STUDY

Pages

 Start Page 33 | End Page 37

Abstract

 Wound contamination and infection that could be caused by distant endogenous infective foci is one of the complications in surgical wound healing. The objective of this study was to evaluate the effect of a remote inoculated infective source on the process of surgical wounds healing, histopathologically. Thirty white New - Zealand rabbits of both sexes weighing about 1.8 kg divided randomly into six equal groups (three of them treated and others as control). In treated groups 24 hours before surgical intervention Staph. aurous (8 x 108 CFU/ ml dilution) was injected subcutaneously in right thigh at the dose rate of 5ml/kg b.w. In both reated and control groups after routine 3Urgical preparation, skin and left orgasms dorsi muscle were incised (3 cm/kg/b.w.) and sutured, immediately Vital signs were assessed before and after operation. Wound tissue specimens were obtained at 24, 43 and 72 hours post - operation from all the animals according to their groups and prepared for histopathological examinations. Clinical assessment showed that in treated groups there were a statistically significant increase in rectal temperature 24 hours after inoculation of Staph aureus(P<0.05). The results of the inflammatory and infective patterns drive from histopathological examinations in treated and control groups were 60% versus 40%, 80% versus 40%, and 80%versus 20%in 24, 48 and 72 hours interval, respectively. In the other words, the histopathological findings revealed obvious wound contamination in the treated group by the rate of 73.3% in contrast to 33.3% for the control group. In this study the presence of considerable histological changes in wounds of treated animals in comparison with control groups, suggested that microorganisms lodged in any part of body other than wound region could affect it, and interfere with its healing process.

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