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Title

PROTECTIVE EFFECT OF BROCCOLI SPROUTS POWDER AGAINST METABOLIC FRUCTOSE-INDUCED METABOLIC DISORDERS IN RATS

Pages

 Start Page 308 | End Page 314

Abstract

 Background and Aim: In this study, we aimed to investigate whether a diet rich in HIGH-sulforaphane BROCCOLI SPROUTs powder (BSP) could attenuate metabolic abnormalities induced by HIGH-fructose corn syrup (HFCS).Materials and Methods: Forty-eight male wistar rats with similar average body weight (253±23g) were randomly allocated into four groups: Baseline control, control (C) (normal diet), fructose (F) (normal diet + water containing 30% fructose), and fructose + BSP (F+B) (diet with 5% BSP + water containing 30% fructose), and followed for 8 weeks. Biochemical measurements including fasting serum triglyceride levels, total cholesterol, HDL-C, alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase were assessed at baseline, and the fourth and eighth weeks.Results: The mean change of body weight was 31.5%, 31.4% and 18.3% in the C, F, and F+B groups, respectively; the mean weight gain of group F+B was lower than those of the other groups (p=0.009). A significant increasing trend was observed in serum total cholesterol, triglycerides and LDL-C levels in group F during the intervention (p<0.05). Serum alkaline phosphatase and gamma-glutamyl transferase also showed a significant increasing trend in group F (p<0.05). After 8-weeks of intervention, in group F+B, LDL-C was significantly lower (p=0.001) and HDL-C was significantly HIGHer (p=0.048) than the other groups.Conclusion: HIGH-sulforaphane BROCCOLI SPROUTs could have favorable effects against METABOLIC DISORDERS-induced by a HIGH fructose diet.

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