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Journal: JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC) | Year:1389 | Volume:4 | Issue:14 | Start Page:61 | End Page:67

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Title

SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF TRIAMTERENE AND HYDROCHLOROTHIAZIDE IN TRIAMTERENE-H TABLETS USING CONTINUOUS WAVELET TRANSFORMATION

Pages

 Start Page 61 | End Page 67

Abstract

 A spectrophotometric method for simultaneous analysis of TRIAMTERENE and HYDROCHLOROTHIAZIDE is proposed by application of CONTINUOUS WAVELET TRANSFORM on the spectral data without time-consuming extraction step.Different wavelets families were tested and Coiflets wavelet family (coif1) and Reverse birothogonal wavelets family (rbio 2.8) were selected and applied under the optimal conditions for simultaneous analysis.The validation of the developed methods was confirmed by analyzing various synthetic mixtures of the investigated drugs.Triamterene and HYDROCHLOROTHIAZIDE could be determined simultaneously in the range of 0.75-5.0 mg ml-1 and 1.0– 6.0 mg. ml-1 respectively and LOD for TRIAMTERENE and HYDROCHLOROTHIAZIDE was less than 1.07 mg. ml-1 and 0.89 mg. ml-1 respectively.The experimental results obtained from the CONTINUOUS WAVELET TRANSFORM approach were statistically compared with those obtained by derivative spectrophotometry and successful results were reported.

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