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Title

CLONIDINE INJECTION (I.P.) AFFECT WITHDRAWAL SYNDROME IN MORPHINE DEPENDENT MALE RATS

Pages

 Start Page 41 | End Page 48

Abstract

 Adrenergic neurotransmission plays important role in opiate withdrawal. In this study the effect of alpha-2 agonist (clonidine) on opiate withdrawal were studied because there are opposite reports about its actions. Animals divided to 4 groups: Control and three groups that they received CLONIDINE in three doses (0.02 mg /kg, 0.2 mg/kg and 2 mg/kg). Animals were addicted by injection of MORPHINE and WITHDRAWAL SYNDROME was induced with injection of 20mg/kg (i.p.) naloxone. Withdrawal signs were evaluated for 30 min.Clonidine had not affected grooming, paw tremor and ejaculation and other sign such as body tremor in doses.0.02 mg/kg (P£0.02), 0.2 mg/kg) P£0.04 (and 2 mg/kg) P£0.002), defecating in doses 0.02 mg/kg (P£0.015), 0.2 mg/kg) P£0.039 (and 2 mg/kg) P£0.015), chewing in doses 0.02 mg/kg (P£0.0001), 0.2 mg/kg) P£0.001 (and 2 mg/kg) P£0.001), teeth chattering in doses 0.0 2mg/kg (P£0.02), 0.2 mg/kg) P£0.01 (and 2 mg/kg P£0.02) and wet dog shakes in doses. 0.02 mg/kg (P£0.026), 0.2 mg/kg) P£0.011 (and 2 mg/kg) P£0.034) decreased significantly. This drug increased standing on feet (P£0.02 (and jumping (P£0.005) in 2 mg/kg dose. It seems that CLONIDINE decreased signs by induce endogenous opiate release or affects alpha-2 receptors and inhibit noradrenalin release Enhancement of signs may be related to CLONIDINE action on the other receptors such as a1-adrenoceptors or imidazoline receptors.

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