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Information Journal Paper

Title

EFFECT OF CANNABINOIDERGIC DRUGS IN THE DORSAL HIPPOCAMPUS OF MORPHINE SENSITIZED RATS IN THE MEMORY FORMATION

Pages

  57-67

Abstract

 In present study, the effects of intra-dorsal hippocampal (intra-CA1) injection of cannabinoid receptor agents on memory formation have been investigated in 3-days MORPHINE-treated rats. Method: Passive avoidance task of memory has been used to examine for retrieval of memory formation, 24 h after training. MORPHINE was injected subcutaneously (S.C.), once daily for 3-days followed by 5 days free of the MORPHINE before training.Results: Post-training intra-CA1 administration of cannabinoid receptor agonist, WIN55, 212-2 (0.25 and 0.5 mg/rat) and CB1 receptor antagonist, AM251 (25 and 50 ng/rat, intra–CA1) decreased memory retrieval. Administration of AM251 (25, 50 and 100 ng/rat, intra - CA1), 2 min before injection of effective dose of WIN55, 212-2 (0.5 mg/rat) decreased the response induced by WIN55, 212-2. Repeated administration of different doses of MORPHINE (2.5, 5 and 10 mg /kg) for 3-days incraesed memory retrieval. However, repeated administration of different doses of MORPHINE (2.5, 5 and 10 mg /kg) for 3-days reversed amnesia induced by WIN55, 212-2.Conclusion: The results suggest that cannabinoidergic and opioidegic system have a close interaction on memory retrieval and WIN55, 212-2 influence on memory formation and subchronic MORPHINE pre-treatment may restore memory through a possible opioidergic receptor SENSITIZATION.

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