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Title

THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS

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 Start Page 41 | End Page 48

Abstract

 Background: Although hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. had Anticonvulsants effect on PTZ-induced kindling SEIZURE behavior, but on the AMYGDALA KINDLING in RATs induced SEIZURE has not been investigated.Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolensL. on SEIZUREs using electrical AMYGDALA KINDLING model.Methods: RATs were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (i.p.100, 200 and 400 mg/kg) and After discharge Duration (ADD), Stage 4 latency (S4L) and Stage 5 duration (S5D) were recorded.Results: Hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (200 and 400 mg/kg) significantly increased stage 4 latency compare to the control group (P<0.05). Hydro-alcoholic extracts of Anethum graveolensL. (400 mg/kg) injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (100, 200 and 400 mg/kg) injection significantly reduced ADD induced by AMYGDALA KINDLING.Conclusion: The data showed that injection of hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. has anti-epileptic effect and increases the time required for AMYGDALA KINDLING and may have anticonvulsant effects.

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