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Information Journal Paper

Title

EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE

Pages

 Start Page 43 | End Page 47

Abstract

 Different studies showed that the root of VALERIAN OFFICINALIScontains free amino acid like GABA and other material like Valeric acid and Isovalerat. Also showed that GABA, Valeric acid and Isovalerat had anticonvulsant effects in animal SEIZURE models. In traditional medicine anticonvulsant effect of VALERIAN OFFICINALISis reminded. In this study anticonvulsant effect of VALERIAN OFFICINALIS using standard method of making chemical SEIZURE with PTZ in MICE, was studied. After measuring SEIZURE threshold with PTZ in control group, different doses of VALERIAN OFFICINALIS (0.25, 0.5, 1 g/kg) orally administrated. Results showed that the PTZ SEIZURE threshold was 35.52 0.85 mg/kg in control group. In animals pretreated with VALERIAN OFFICINALIS the PTZ SEIZURE threshold showed dose dependently increased (p<0.05). In conclusion results showed that: the mechanism of anticonvulsant effect of VALERIAN OFFICINALIS probably is via GABAergic effect of this agent. This subject needs to be more investigation in human.

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